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KMID : 0363320200410061119
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Journal of Korean Oriental Internal Medicine
2020 Volume.41 No. 6 p.1119 ~ p.1140
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Recent Trends in Clinical Research on Herbal Medicine Based on Pinellia Ternata for Treatment of Gastroesophageal Reflux Disease
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Jang Hye-Yeon
Kim Young-Kwang
Jeong Seo-Yun
Kim Do-Hyeong
Kim Kyeong-Ok
Lee Young-Su
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Abstract
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Objective: The purpose of this study was to review Chinese clinical studies of the treatment of gastroesophageal reflux disease (GERD) with herbal medicine including Pinellia ternata.
Methods: We searched the China National Knowledge Infrastructure (CNKI) database for clinical studies on herbal treatments including Pinellia ternata for GERD, from January 1st, 2015 to September 30th, 2019. We evaluated the risk of bias using Cochrane’s risk of bias to confirm the quality of the 37 selected documents.
Results: The 37 papers included high-dose and middle-dose Pinellia ternata groups. The outcome measures included treatment effectiveness rate, symptom comparisons, and endoscopy effectiveness rates or scores. In both groups, most studies showed significant improvement in the treatment group compared with the control group. The meta-analysis revealed a higher treatment effectiveness rate and a lower recurrence rate in the treatment group than in the control group.
Conclusions: Comparing the treatment effect between the two groups was difficult due to the low quality of most studies. However, the results suggest that herbal remedies including Pinellia ternata showed statistically significant improvement in GERD compared to control groups.
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KEYWORD
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gastroesophageal reflux disease (GERD), herbal medicine, traditional Chinese medicine (TCM), Pinellia ternata (半夏)
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